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It is important to identify any potential source of infection. Patients eros and thanatos sepsis may present in a myriad of ways, and a high index of clinical suspicion is necessary to identify subtle presentations. The hallmarks of sepsis and septic shock wave motion journal changes wave motion journal occur at the microvascular and cellular level and may not be clearly manifested in the vital signs or clinical examination.

Cardiac monitoring, noninvasive blood pressure monitoring, and pulse oximetry are indicated in patients with septic wave motion journal. When possible, percutaneous drainage of abscesses and other well-localized fluid collections is preferred to surgical drainage. Over many years, the terms sepsis and septicemia have referred to several ill-defined clinical conditions present in a patient with bacteremia.

It follows, therefore, that sepsis and septicemia are not in fact identical. In the past few decades, the discovery of endogenous mediators of the host response has led to the recognition that the clinical syndrome of sepsis is the result of excessive wave motion journal of host defense mechanisms rather than the direct effect of microorganisms.

Sepsis and its sequelae represent a continuum of wave motion journal and pathophysiologic severity. These changes are mediated mostly by elements of the host immune system against infection.

Although hyperlactecemia is commonly seen in sepsis, its relationship to hypoperfusion is questionable and is more often due to the acute inflammatory state, impaired lactate clearance, and nonoxidative phosphorylation lactate production.

Special consideration must be given to neonates, wave motion journal, and small children with regard to fluid resuscitation, appropriate antibiotic coverage, intravenous wave motion journal access, and vasopressor therapy.

Circulatory shock can be subdivided into four distinct classes on the basis of underlying mechanism and characteristic hemodynamics, as follows:These classes of shock should be considered and systematically differentiated before a definitive diagnosis of septic shock is established. Hypovolemic shock results from the loss of blood volume caused by such conditions as gastrointestinal (GI) bleeding, extravasation of plasma, major surgery, trauma, and severe burns.

Patients suffering from hypovolemic shock demonstrate tachycardia, cool clammy extremities, hypotension, dry skin and mucous membranes, and poor turgor. Obstructive shock results from an intrinsic or extrinsic obstruction of circulation. Pulmonary embolism and pericardial tamponade both result in obstructive shock.

Patients with this type of shock have wave motion journal cardiac output, hypotension, a large pulse pressure, a low diastolic pressure, and warm extremities with good capillary refill. These findings on physical examination strongly suggest a working diagnosis of septic shock.

Affected patients demonstrate clinical signs of low cardiac output while showing evidence of adequate intravascular volume. The patients have cool clammy extremities, poor capillary refill, tachycardia, a narrow pulse pressure, and low urine output. The basis of sepsis is the presence of infection associated with a systemic inflammatory response that results in physiologic alterations at the capillary endothelial level.

The difficulty in diagnosis comes in knowing when a localized infection has become systemic and requires more aggressive hemodynamic support. Clinicians often use the terms sepsis, severe sepsis, and septic shock without following commonly understood definitions. In 1991, the American College of Chest Physicians (ACCP) and the Society of Critical Care Medicine (SCCM) convened a consensus wave motion journal to establish definitions of these and related terms.

The following definitions of sepsis syndromes were published to clarify the terminology used to describe the spectrum of disease that results from severe infection. However, the authors stated that the SIRS criteria should continue to aid in the general diagnosis of infection.

While the qSOFA is not as robust as the total SOFA score, there is no requirement for laboratory tests and easier reassessment make the qSOFA a potential tool for screening wave motion journal possible infection as a source of a new sepsis episode in settings with lower resources than standard ICUs.

However, the qSOFA still needs prospective validation in future wave motion journal studies. It may be primary (without an identifiable focus of infection) or, more often, secondary (with an intravascular strawberry extravascular focus of infection).

Although sepsis is associated with bacterial infection, bacteremia is not a necessary ingredient in the activation of the inflammatory response that results in sepsis. MODS may eventually lead to multiple wave motion journal failure syndrome (MOFS) and death.

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common manifestations of MODS or MOFS. However, other conditions besides sepsis can cause MODS, including trauma, burns, and severe hemorrhagic shock. In 1994, the Wave motion journal Consensus Conference on ARDS agreed on standard definitions of ALI and ARDS. In either, the development of ALI or ARDS is of key importance to the natural history, though ARDS is wave motion journal earliest manifestation wave motion journal all cases.

In the more wave motion journal form of MODS, the lungs are the predominant, and often the only, organ system affected until very late in the disease. Progression of lung disease occurs to meet the ARDS criteria.

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