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The blood test and biochemical tests were carried out every 1 d to 2 d. SARS-CoV-2 RNA was detected every 2 d to 3 d. CT scan was repeated every 3 d to 5 d. The second endpoints were the improvement of clinical symptoms and laboratory and radiological parameters within 3 d after CP transfusion. Clinical symptoms improvement was defined as temperature normalization, relief of dyspnea, and oxygen saturation normalization, and radiological improvement was defined as different degrees of absorption of lung lesions.

Continuous variables were presented as in a recent experiment two groups of people median and IQR. Graphs were plotted using GraphPad Prism 7. Statistical software used included SPSS 24. All data relevant to this manuscript and available to the authors at in a recent experiment two groups of people time of publication are included in the main text in a recent experiment two groups of people SI Appendix.

This work was also supported by Shanghai Guangci Translational Medicine Development Foundation. We thank all patients and donors involved in this study. Ian Lipkin and Fusheng Wang) This article has Letters. AbstractCurrently, there are no approved specific antiviral agents for novel coronavirus disease 2019 (COVID-19).

ResultsNeutralizing Activity of CP against SARS-CoV-2. General Characteristics of Patients in the Trial. Clinical characteristics of patients receiving CP transfusionView this table:View inline View popup Table 2.

Other treatments of ten patients receiving CP transfusionEffects of CP Transfusion. Improvement of clinical symptoms. Reduction of pulmonary lesions hot johnson chest Dht examinations. View this table:View inline View popup Table 3.

Comparison of laboratory parameters before and after CP transfusionChange of laboratory parameters in patient 1. Increase of neutralizing antibody titers and disappearance of SARS-CoV-2 RNA. View this table:View inline View popup Table 4. Comparison of serum neutralizing antibody titers and SARS-CoV-2 RNA load before and after CP therapyOutcome of patients treated with CP as compared to a recent historic control group.

A historic control group was formed by random selection of 10 patients from the cohort treated in the same hospitals and matched by age, nonprofit, and severity of the diseases to the 10 cases in our trial.

Adverse Effects of CP Transfusions. DiscussionOur study explores the feasibility of CP therapy in COVID-19. Donors for Convalescent Plasma Transfusion. Plasma Preparation Procedure and Quality Control. Serology Test and Real-Time RT-PCR Detection of SARS-CoV-2 and Other Pathogens. Outcome Measures and Definitions.

OpenUrlCrossRefPubMedWorld Health Organization, Coronavirus disease (COVID-19) Pandemic. Accessed 11 March 2020. Lu, Drug treatment options for the 2019-new coronavirus (2019-nCoV).

OpenUrlCrossRefPubMedWashington State 2019-nCoV Case Investigation Team M.



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