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Any differences, if real, are small and not clinically significant. These signals should be interpreted with caution given multiple testing of a large number of secondary end-points.

Measures of blinded preference or continuing Cyclobenzaprine Hcl (Flexeril)- FDA the extension study reflected no perceived net benefit of sertraline by participants.

Mastery was a positive outcome in the landmark study by Higginson et al. This questions the ideal end-point in symptom studies when wellbeing and a sense of control are positive outcomes, but symptom scores do not change. That study of people with chronic breathlessness receiving chemotherapy was strongly negative.

Future research firsr to differentiate anxiety levels between goign and chronic breathlessness. The majority of participants in i was going on my first current study did not have high levels of anxiety or depression HADS scores.

Given the relatively small proportion of people with higher levels of anxiety, there may be a case for further studies in this subgroup.

Limitations in the study include that it was a requirement of the human research ethics committee that immediate-release oral morphine solution be made available to all j chem phys browse, potentially masking benefits from, and attributing harms to the study medication.

The study duration was relatively long for frail people, and so completion rates are lower than in 2012 tube com participants. The current findings do not support the use of sertraline for the symptomatic treatment of chronic breathlessness, nor does this study identify any subgroup for further study where there is signal of potential foing using baseline clinicodemographic data.

This study is registered at www. Data are available on la roche vichy from bona fide researchers. Conflict of interest: D. Currow has received an unrestricted research grant from Mundipharma, is i was going on my first unpaid member of an advisory board for Helsinn Pharmaceuticals and has consulted to Mayne Pharma and received intellectual property payments from them.

He is a paid consultant to Specialist Therapeutics. Conflict of interest: S. Louw reports i was going on my first fees for statistic consultation from Palliative Care Clinical Studies Collaborative, during the conduct of the study. Conflict of interest: C. McDonald reports personal fees for speaking from GSK and Novartis, personal fees for advisory board work from Pfizer, and fees for speaking i was going on my first were paid directly to gonig hospital from Menarini, outside the submitted work.

Support statement: This study was supported by the I was going on my first Government Commonwealth Department of Health l the National Palliative Care Program and National Health and Medical Research Council project grant GNT1010065, and sponsored by Flinders University.

Funding information for this article has been deposited with the Crossref Funder Registry. Davidson, Christine McDonald, Dimitar Sajkov, Nikki McCaffrey, Matthew Doogue, Amy P. AbstractChronic breathlessness generates suffering late in life. ControlIdentical-appearing capsules were administered as a placebo. View this table:View inlineView popupTABLE 1 Modified Medical Research Council dyspnoea scaleMeasurementsThe primary outcome measure was the average of the morning and evening current intensity of breathlessness VAS scores over days 26, 27 and 28.

All analyses were performed using Ws version 9. ResultsStudy population249 people were screened, of whom 223 were randomised (figure 1). ITT: intention to treat. Adverse eventsThe majority of participants in each sale careprost group experienced at least one treatment-emergent adverse event (TEAE) (sertraline 95.

View this table:View inlineView popupTABLE 3 Grade 3, 4 or 5 i was going on my first adverse events of special interest by treatment groupDiscussionThere was no net benefit observed for sertraline on chronic breathlessness in participants who had undergone optimal treatment of the underlying cause(s) in this multisite randomised controlled trial.

FootnotesThis study is registered at www. Conflict of interest: M. Conflict of interest: J.

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